What is the therapeutic index?

What is the therapeutic index?

• A. The ratio of a drug's safe dose to its effective dose
• B. The ratio of a drug's toxic dose to its therapeutic dose
• C. The percentage of patients who benefit from a drug
• D. The amount of time required for a drug to take effect

Answer: (B)

The therapeutic index is defined as the ratio of the toxic dose of a drug to its therapeutic dose. This measurement provides crucial information about the safety and efficacy of a medication. A high therapeutic index indicates that there is a wide margin between the doses that can cause toxicity and those that produce the desired therapeutic effect, suggesting that the drug is relatively safe to use. A therapeutic index that is low, on the other hand, means there is a smaller margin between effective and toxic doses, which requires careful monitoring when administering the drug to avoid adverse effects. This concept is essential for healthcare professionals when considering dosages for patients. By understanding the therapeutic index, clinicians can ensure that they prescribe medications that are both effective and safe, weighing the benefits of treatment against the potential risks of toxicity. While other options might relate to drug administration and effectiveness, they do not capture the specific relationship between safe and toxic doses that defines the therapeutic index.

The therapeutic index is defined as the ratio of the toxic dose of a drug to its therapeutic dose. This measurement provides crucial information about the safety and efficacy of a medication. A high therapeutic index indicates that there is a wide margin between the doses that can cause toxicity and those that produce the desired therapeutic effect, suggesting that the drug is relatively safe to use.

A therapeutic index that is low, on the other hand, means there is a smaller margin between effective and toxic doses, which requires careful monitoring when administering the drug to avoid adverse effects.

This concept is essential for healthcare professionals when considering dosages for patients. By understanding the therapeutic index, clinicians can ensure that they prescribe medications that are both effective and safe, weighing the benefits of treatment against the potential risks of toxicity.

While other options might relate to drug administration and effectiveness, they do not capture the specific relationship between safe and toxic doses that defines the therapeutic index.